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Primary Role of the Nucleosome

August 6, 2020 0

Summary: The coiling of DNA in the core nucleosome inhibits the initiation of transcription. The core nucleosome thus serves as a general gene repressor and prevents pervasive intergenic and intragenic transcription. This fundamental regulatory role of the nucleosome apparently emerged before the acquisition of the histone tails. Source: Molecular Cell […]

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Amplifying the Noise: Oncometabolites Mask an Epigenetic Signal of DNA Damage

August 6, 2020 0

Summary: A recent study (Sulkowski et al., 2020) reveals that oncometabolites, which are produced by metabolic gene mutations in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obscuring epigenetic marks that are necessary for efficient DNA repair. Source: Molecular Cell Read More

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Unwinding the Role of FACT in Cas9-based Genome Editing

August 6, 2020 0

Summary: In a recent issue of Molecular Cell, Wang et al. (2020) employ unbiased proteomics approaches and live-cell imaging to reveal a key role for the histone chaperone complex FACT (SPT16 and SSRP1) in governing Cas9 turnover at the DNA target site during genome and epigenome editing. Source: Molecular Cell Read […]

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TDP-43 Nuclear Bodies: A NEAT Response to Stress?

August 6, 2020 0

Summary: In this issue of Molecular Cell, Wang et al. (2020) investigate stress-induced nuclear condensates of the RNA-binding protein TDP-43, uncovering a protective function for these granules as well as an RNA-dependent mechanism for scaffolding them. Source: Molecular Cell Read More

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Looping the (R) Loop in DSB Repair via RNA Methylation

August 6, 2020 0

Summary: In this issue of Molecular Cell, Zhang et al. (2020) reveal that ATM triggers RNA methylation of DNA-RNA hybrids formed at double-strand breaks (DSBs) to modulate repair, adding a new layer of complexity to RNA’s role in the DNA damage response. Source: Molecular Cell Read More

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Structure of the Inhibited State of the Sec Translocon

July 20, 2020 0

Summary: Gérard et al. determine the structure of the mammalian Sec translocon in an inhibited state. Mycolactone holds the translocon in a conformation optimal for substrate engagement, wedging open the cytosolic side of the lateral gate, while also blocking the path taken by the signal peptide during engagement. Source: Molecular Cell […]

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Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity

July 16, 2020 0

Summary: Zhang et al. profiled endogenous deubiquitinase activity in virus infection and identified OTUD3 as an acetylation-dependent deubiquitinase that restricts innate antiviral immune signaling. Lys129-acetylated OTUD3 showed significantly enhanced activity for the Lys63 linkage on MAVS, and RNA virus-activated SIRT1 turned it off, allowing innate immune signals to quickly and effectively […]