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ESCRTs cut some slack

August 3, 2020 0

Summary: Nature Cell Biology, Published online: 03 August 2020; doi:10.1038/s41556-020-0557-1In this issue of Nature Cell Biology, Mercier et al. show that acute changes in membrane tension may be a physiological trigger for ESCRT assembly, which drives membrane scission, luminal vesicle budding, and a wide array of other membrane remodelling events […]

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Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma

August 3, 2020 0

Summary: Nature Cell Biology, Published online: 03 August 2020; doi:10.1038/s41556-020-0547-3Profiling phenotype switching in melanoma. Wouters et al. perform large-scale gene expression analysis in patient samples and identify transcriptional networks that modulate the intermediate cell state and ultimate mesenchymal switching in melanoma. Source: Nature Cell Biology – Issue – nature.com science […]

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A bridge between melanoma cell states

August 3, 2020 0

Summary: Nature Cell Biology, Published online: 03 August 2020; doi:10.1038/s41556-020-0556-2Cellular plasticity allows tumours to adapt to and overcome therapeutic challenges. A recent study uncovered the gene regulatory networks that govern cell states and phenotype switching in melanoma, opening up possibilities to therapeutically target cell states or phenotypic plasticity to render […]

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Oncogenic splicing regulated by phase separation

July 27, 2020 0

Summary: Nature Cell Biology, Published online: 27 July 2020; doi:10.1038/s41556-020-0553-5There is increasing appreciation that many proteins self-aggregate in cells to form functional subcompartments, some of which exist as a separate liquid phase. A study now identifies the biophysical properties of AKAP95 protein condensates as critical for supporting cancer cell proliferation […]

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Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

July 20, 2020 0

Summary: Nature Cell Biology, Published online: 20 July 2020; doi:10.1038/s41556-020-0545-5Sato et al. demonstrate that IRF2, which negatively regulates interferon signalling, safeguards intestinal stem cells against non-infectious, sterile interferon stress by limiting their differentiation into secretory lineages. Source: Nature Cell Biology – Issue – nature.com science feeds Read More