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Hhex drives B cells down memory lane

August 7, 2020 0

Summary: Nature Immunology, Published online: 07 August 2020; doi:10.1038/s41590-020-0763-9The combination of single-cell RNA-seq and in vivo CRISPR–Cas9 screens reveal a new circuit that directs germinal center B cells toward a memory B cell phenotype during viral infection. Source: Nature Immunology – Issue – nature.com science feeds Read More

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Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

August 3, 2020 0

Summary: Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0751-0Autophagy controls cellular homeostasis and influences immune responses. Galluzzi and colleagues show that tumor cell autophagy opposes inflammatory cell death following radiation therapy and can be inhibited to enhance antitumor responses. Source: Nature Immunology – Issue – nature.com science feeds Read More

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In situ neutrophil efferocytosis shapes T cell immunity to influenza infection

August 3, 2020 0

Summary: Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0746-xKim and colleagues provide new insights into the function and fate of neutrophils during influenza infection and their roles in antiviral T cell responses. Source: Nature Immunology – Issue – nature.com science feeds Read More

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The mesenchymal context in inflammation, immunity and cancer

August 3, 2020 0

Summary: Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0741-2Koliaraki, Prados, Armaka & Kollias review the roles of fibroblastic mesenchymal cells in tissue homeostasis and immunopathologic diseases, including chronic inflammatory disease, tissue fibrosis and cancer. Source: Nature Immunology – Issue – nature.com science feeds Read More

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Mapping systemic lupus erythematosus heterogeneity at the single-cell level

August 3, 2020 0

Summary: Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0743-0Banchereau and colleagues provide a resource dataset that examines disease-related transcriptional profiles of peripheral whole-blood cells from adolescent patients with SLE by single-cell RNA-seq analysis. Source: Nature Immunology – Issue – nature.com science feeds Read More

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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung

August 3, 2020 0

Summary: Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0745-yPathological group 2 innate lymphoid cells (ILC2s) have mainly been implicated in allergy. Halim and colleagues demonstrate that ILC2s orchestrate a prometastatic pathway via the recruitment of eosinophils that suppress NK cell function. Source: Nature Immunology – Issue – nature.com science feeds […]

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Make killers sweeter: targeting metabolic checkpoints of NK cells

August 3, 2020 0

Summary: Nature Immunology, Published online: 03 August 2020; doi:10.1038/s41590-020-0738-xGroup 2 innate lymphoid cells (ILC2s) closely intersect with antitumor immunity. A new study describes how activation of lung-resident ILC2s orchestrates the suppression of natural killer cell–mediated innate antitumor immunity via an eosinophil-mediated metabolic mechanism. Source: Nature Immunology – Issue – nature.com […]

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NRP1 cripples immunological memory

July 28, 2020 0

Summary: Nature Immunology, Published online: 28 July 2020; doi:10.1038/s41590-020-0759-5Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory. Source: Nature Immunology – Issue – nature.com […]

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A bacteria–chemokine double act repairs the skin

July 27, 2020 0

Summary: Nature Immunology, Published online: 27 July 2020; doi:10.1038/s41590-020-0755-9A complex formed by the chemokine CXCL10 and commensal skin microbiota–derived DNA is a crucial component that triggers type I IFN responses to facilitate skin repair. Source: Nature Immunology – Issue – nature.com science feeds Read More