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Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis

August 3, 2020 0

Summary: Nature Microbiology, Published online: 03 August 2020; doi:10.1038/s41564-020-0762-5This study describes the mechanism by which Chlamydia trachomatis reprogrammes host glutamine metabolism in a c-Myc-dependent manner. The authors show that glutamine uptake via the SLC15A transporter and glutaminolysis are crucial for peptidoglycan synthesis and Chlamydia replication. Source: Nature Microbiology – nature.com […]

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Genetic circuit design automation for yeast

August 3, 2020 0

Summary: Nature Microbiology, Published online: 03 August 2020; doi:10.1038/s41564-020-0757-2This study describes design automation and predictable gene regulatory network engineering in a eukaryotic microorganism. Source: Nature Microbiology – nature.com science feeds Read More

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Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements

July 27, 2020 0

Summary: Nature Microbiology, Published online: 27 July 2020; doi:10.1038/s41564-020-0760-7This study reveals that prion-like domains support the assembly of transcription factor complexes that control fungal cell identity and highlights parallels with the ‘super-enhancers’ that regulate mammalian cell fate. Source: Nature Microbiology – nature.com science feeds Read More

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Structures of capsid and capsid-associated tegument complex inside the Epstein–Barr virus

July 27, 2020 0

Summary: Nature Microbiology, Published online: 27 July 2020; doi:10.1038/s41564-020-0758-1This study reveals features of Epstein–Barr virus that are similar but not identical to the closely related Kaposi’s sarcoma-associated herpesvirus. The authors provide locations of protein components within the viral capsid and reveal different conformers of protein components by revealing variations in […]

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Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli

July 27, 2020 0

Summary: Nature Microbiology, Published online: 27 July 2020; doi:10.1038/s41564-020-0763-4Subinhibitory levels of sulfamethoxazole, an antibiotic used to treat Escherichia coli infections, trigger a previously undescribed metabolic pathway in E. coli that comprises a family of hybrid pterin–phenylpyruvate conjugates called colipterins. These metabolites are antioxidants, have immunomodulatory properties and improve colitis in […]

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Research funding after COVID-19

July 24, 2020 0

Summary: Nature Microbiology, Published online: 24 July 2020; doi:10.1038/s41564-020-0768-zResearch funding after COVID-19 Source: Nature Microbiology – nature.com science feeds Read More

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What has the World Health Organization done for us?

July 24, 2020 0

Summary: Nature Microbiology, Published online: 24 July 2020; doi:10.1038/s41564-020-0772-3We reflect on why we need the World Health Organization now more than ever. Source: Nature Microbiology – nature.com science feeds Read More

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Glycan degradation writ large in the ocean

July 24, 2020 0

Summary: Nature Microbiology, Published online: 24 July 2020; doi:10.1038/s41564-020-0765-2Marine bacteria that produce an enormous panoply of glycan-degrading enzymes are identified as having a role in releasing fixed carbon present in glycan-rich cell walls of brown algae. Source: Nature Microbiology – nature.com science feeds Read More

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Dual-mechanism antibiotics

July 24, 2020 0

Summary: Nature Microbiology, Published online: 24 July 2020; doi:10.1038/s41564-020-0767-0A dual-mechanism compound with antibacterial activity that targets both folate metabolism and membrane integrity, with a favourable resistance profile in vitro, is identified by screening a small molecule library. Source: Nature Microbiology – nature.com science feeds Read More