No Image

Trial of Roflumilast Cream for Chronic Plaque Psoriasis

July 16, 2020 0

Summary: High-potency topical glucocorticoids and vitamin D derivatives are the main treatments for psoriasis. Topical glucocorticoids are effective in the treatment of psoriasis, but their use is usually limited to no more than 2 to 8 weeks, and they may be associated with adverse events that resolve… Source: The New […]

No Image

PRIME Time in Rheumatoid Arthritis

July 16, 2020 0

Summary: Rheumatoid arthritis, like many autoimmune diseases, has a course characterized by intermittent flares, yet our understanding of the mechanisms underlying flares remains limited. In an article published in this issue of the Journal, Orange and colleagues describe a study in which serial fingerstick… Source: The New England Journal of […]

No Image

RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares

July 16, 2020 0

Summary: Rheumatoid arthritis symptoms are highly dynamic, with periods of stability interrupted by unpredictable flares of disease activity. Such waxing and waning clinical courses are characteristic of many autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and inflammatory… Source: The New England Journal of Medicine: Search Results in AllergyImmunology Read […]

No Image

Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus

July 9, 2020 0

Summary: The inflammatory skin condition atopic dermatitis is a chronic, relapsing disease characterized by epidermal-barrier disruption, T-cell activation, and imbalance of the skin microbiome. The pathogenesis of atopic dermatitis is primarily driven by type 2 helper T (Th2) lymphocytes, with considerable… Source: The New England Journal of Medicine: Search Results […]

No Image

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

June 29, 2020 0

Summary: The coronavirus disease 2019 (Covid-19) pandemic has caused catastrophic disease worldwide, although children have been relatively spared. Severe lung involvement with acute respiratory failure is the most common complication of Covid-19 in adults, but many have complications in multiple organs,… Source: The New England Journal of Medicine: Search Results […]

No Image

Multisystem Inflammatory Syndrome in Children in New York State

June 29, 2020 0

Summary: Since December 2019, the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has resulted in high morbidity and mortality worldwide. New York State emerged as an epicenter of the outbreak in the United States,… Source: The New England Journal […]

No Image

Tofacitinib for Refractory Immune-Related Colitis from PD-1 Therapy

June 11, 2020 Admin 0

Category: Summary: To the Editor: In the OCTAVE trials, the Janus kinase (JAK) inhibitor tofacitinib was established as a new therapeutic strategy for patients with ulcerative colitis refractory to biologic agents. A similar clinical need exists in patients affected by immune-related colitis, the complication that… Source: The New England Journal […]