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JoF, Vol. 6, Pages 128: Natural Products from Endophytic Fungi Associated with Rubiaceae Species

August 7, 2020 0

Summary: This review presents the chemical diversity and pharmacological properties of secondary metabolites produced by endophytic fungi associated with various genera of Rubiaceae. Several classes of natural products are described for these endophytes, although, this study highlights the importance of some metabolites, which are involved in antifungal, antibacterial, anti-protozoal activities; […]

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Pharmaceuticals, Vol. 13, Pages 184: Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones

August 7, 2020 0

Summary: Short-chain quinones (SCQs) have been identified as potential drug candidates against mitochondrial dysfunction, which largely depends on the reversible redox characteristics of the active quinone core. We recently identified 11 naphthoquinone derivatives, 1–11, from a library of SCQs that demonstrated enhanced cytoprotection and improved metabolic stability compared to the […]

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Antibiotics, Vol. 9, Pages 489: Active Pulmonary Tuberculosis in Elderly Patients: A 2016–2019 Retrospective Analysis from an Italian Referral Hospital

August 7, 2020 0

Summary: Tuberculosis (TB) in the elderly (>65 years old) has increasingly become a global health problem. It has long been recognized that older people are vulnerable to developing tuberculosis. We retrospectively evaluated data from patients older than 65 years diagnosed with pulmonary TB admitted to the National Institute for Infectious […]

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Temporal variations in the distribution of self-harm episodes and methods across the Australian asylum seeker population: An observational study

August 6, 2020 0

Summary: by Kyli Hedrick, Gregory Armstrong, Guy Coffey, Rohan Borschmann Background Temporal patterns in the frequency and characteristics of self-harm episodes across the Australian asylum seeker population may have implications for self-harm prevention and public health policy. The aim of this study was to examine how the distribution of self-harm […]

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Replication of the Salmonella Genomic Island 1 (SGI1) triggered by helper IncC conjugative plasmids promotes incompatibility and plasmid loss

August 6, 2020 0

Summary: by Kévin T. Huguet, Nicolas Rivard, Daniel Garneau, Jason Palanee, Vincent Burrus The mobilizable resistance island Salmonella genomic island 1 (SGI1) is specifically mobilized by IncA and IncC conjugative plasmids. SGI1, its variants and IncC plasmids propagate multidrug resistance in pathogenic enterobacteria such as Salmonella enterica serovars and Proteus […]

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Exposure to COVID-19 patients increases physician trainee stress and burnout

August 6, 2020 0

Summary: by Thomas G. Kannampallil, Charles W. Goss, Bradley A. Evanoff, Jaime R. Strickland, Rebecca P. McAlister, Jennifer Duncan The coronavirus disease 2019 (COVID-19) pandemic has put considerable physical and emotional strain on frontline healthcare workers. Among frontline healthcare workers, physician trainees represent a unique group—functioning simultaneously as both learners […]