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Integrative illustration for coronavirus outreach

August 6, 2020 0

Summary: by David S. Goodsell, Maria Voigt, Christine Zardecki, Stephen K. Burley Two illustrations integrate current knowledge about severe acute respiratory syndrome (SARS) coronaviruses and their life cycle. They have been widely used in education and outreach through free distribution as part of a coronavirus-related resource at Protein Data Bank […]

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Dynamic centriolar localization of Polo and Centrobin in early mitosis primes centrosome asymmetry

August 6, 2020 0

Summary: by Emmanuel Gallaud, Anjana Ramdas Nair, Nicole Horsley, Arnaud Monnard, Priyanka Singh, Tri Thanh Pham, David Salvador Garcia, Alexia Ferrand, Clemens Cabernard Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain an older “mother” and a younger “daughter” centriole. Stem cells either inherit the mother or daughter-centriole-containing […]

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Down-regulation of a cytokine secreted from peripheral fat bodies improves visual attention while reducing sleep in Drosophila

August 3, 2020 0

Summary: by Deniz Ertekin, Leonie Kirszenblat, Richard Faville, Bruno van Swinderen Sleep is vital for survival. Yet under environmentally challenging conditions, such as starvation, animals suppress their need for sleep. Interestingly, starvation-induced sleep loss does not evoke a subsequent sleep rebound. Little is known about how starvation-induced sleep deprivation differs […]

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Selfing mutants link Ku proteins to mating type determination in Tetrahymena

August 3, 2020 0

Summary: by I-Ting Lin, Meng-Chao Yao Recognition of self and nonself is important for outcrossing organisms, and different mating types establish the barrier against self-mating. In the unicellular ciliate T. thermophila, mating type determination requires complex DNA rearrangements at a single mat locus during conjugation to produce a type-specific gene […]

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Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

August 3, 2020 0

Summary: by Shashi Prakash Singh, Peter A. Thomason, Sergio Lilla, Matthias Schaks, Qing Tang, Bruce L. Goode, Laura M. Machesky, Klemens Rottner, Robert H. Insall The Scar/WAVE complex is the principal catalyst of pseudopod and lamellipod formation. Here we show that Scar/WAVE’s proline-rich domain is polyphosphorylated after the complex is […]

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Should a viral genome stay in the host cell or leave? A quantitative dynamics study of how hepatitis C virus deals with this dilemma

July 30, 2020 0

Summary: by Shoya Iwanami, Kosaku Kitagawa, Hirofumi Ohashi, Yusuke Asai, Kaho Shionoya, Wakana Saso, Kazane Nishioka, Hisashi Inaba, Shinji Nakaoka, Takaji Wakita, Odo Diekmann, Shingo Iwami, Koichi Watashi Virus proliferation involves gene replication inside infected cells and transmission to new target cells. Once positive-strand RNA virus has infected a cell, […]