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Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro

August 7, 2020 0

Summary: by Shelton W. Wright, Lara Lovelace-Macon, Deirdre Ducken, Sarunporn Tandhavanant, Prapit Teparrukkul, Viriya Hantrakun, Direk Limmathurotsakul, Narisara Chantratita, T. Eoin West Melioidosis is an often-severe tropical infection caused by Burkholderia pseudomallei (Bp) with high associated morbidity and mortality. Burkholderia thailandensis (Bt) is a closely related surrogate that does not […]

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SARS-CoV-2 infection in China—Before the pandemic

August 6, 2020 0

Summary: by Huiying Liang, Lingling Zheng, Huimin Xia, Jinling Tang In order to rapidly inform polices in the international response to the ongoing pandemic of coronavirus disease 19 (COVID-19), we summarize in this review current evidence on epidemiological and clinical features of the infection, transmission routes, problems of nucleic-acid testing, […]

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Fasciola hepatica Serine Protease Inhibitor Family (Serpins): Purposely crafted for regulating host proteases

August 6, 2020 0

Summary: by Carolina De Marco Verissimo, Heather L. Jewhurst, Irina G. Tikhonova, Rolf T. Urbanus, Aaron G. Maule, John P. Dalton, Krystyna Cwiklinski Serine protease inhibitors (serpins) regulate proteolytic events within diverse biological processes, including digestion, coagulation, inflammation and immune responses. The presence of serpins in Fasciola hepatica excretory-secretory products […]