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[Viewpoint] Defining gaps in pre-exposure prophylaxis delivery for pregnant and post-partum women in high-burden settings using an implementation science framework

August 1, 2020 0

Summary: Pregnancy is a high-risk period for HIV acquisition in African women, and pregnant women who become acutely infected with HIV account for up to a third of vertical HIV transmission cases in African settings. To protect women and eliminate vertical transmission, WHO recommends offering oral pre-exposure prophylaxis (PrEP) based […]

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[Review] Modern diagnostic technologies for HIV

August 1, 2020 0

Summary: Novel diagnostic technologies, including nanotechnology, microfluidics, -omics science, next-generation sequencing, genomics big data, and machine learning, could contribute to meeting the UNAIDS 95-95-95 targets to end the HIV epidemic by 2030. Novel technologies include multiplexed technologies (including biomarker-based point-of-care tests and molecular platform technologies), biomarker-based combination antibody and antigen […]

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[Feature] Highlights of AIDS 2020

August 1, 2020 0

Summary: AIDS 2020 (July 6–10) may not have made it to Oakland and San Francisco, but the reconfigured virtual conference still contained an abundance of science and activism. Source: The Lancet HIV Read More

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[Articles] Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial

August 1, 2020 0

Summary: Adult dolutegravir 50 mg film-coated tablets given once daily provide appropriate pharmacokinetic profiles in children weighing 20 kg or more, with no safety signal, allowing simplified practical dosing and rapid access to dolutegravir. These results informed the WHO 2019 dolutegravir paediatric dosing guidelines and have led to US Food […]

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[Correspondence] HIV programmes in countries within the Asia-Pacific region

August 1, 2020 0

Summary: In their Viewpoint in The Lancet HIV, Ravipa Vannakit and colleagues1 provide an overview of challenges and outline priorities for domestically funded programmes delivered by key population and civil society organisations in the Asia-Pacific region. They acknowledge the diversity within countries; however, they do not offer guidance to these […]

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[Comment] Do integrase inhibitors affect immune restoration?

August 1, 2020 0

Summary: In The Lancet HIV, Sergio Serrano-Villar and colleagues1 report that initiation of a integrase strand-transfer inhibitor (INSTI)-based regimen in patients lead to greater CD4/CD8 ratio recovery compared with a non-nucleoside reverse transcriptase or protease inhibitor-based strategy. To date, this is the largest study to provide such results. Source: The […]

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[Correspondence] Sexual transmission of an extensively drug-resistant HIV-1 strain

August 1, 2020 0

Summary: Emergence of drug-resistant HIV-1 has long been identified as a public health threat.1 However, there has so far been little transmission of multidrug-resistant strains, probably because of reduced replication fitness of highly mutated strains that makes them less adapted for establishing infection than wild-type strains among the viral quasispecies. […]