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[Editorial] Self-determination and Indigenous health

August 8, 2020 0

Summary: Colonisation is a fundamental determinant of Indigenous peoples’ health. Indigenous is a term defined by dislocation, and the effects of that displacement are felt by Indigenous peoples around the world. Aug 9, International Day of the World’s Indigenous Peoples, is a chance to look at the continuing effects of […]

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[Correspondence] Further clinical interpretation and implications of KEYNOTE-048 findings

August 8, 2020 0

Summary: Recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) denotes a difficult-to-treat patient population. Most of these recurrent tumours are pretreated with chemoradiotherapy, and hence could represent resistant tumours that are clonally selected. Although these pretreated tumours are biologically less likely to respond to chemotherapy than tumours that […]

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[Articles] Surgery versus cast immobilisation for adults with a bicortical fracture of the scaphoid waist (SWIFFT): a pragmatic, multicentre, open-label, randomised superiority trial

August 8, 2020 0

Summary: Adult patients with scaphoid waist fractures displaced by 2 mm or less should have initial cast immobilisation, and any suspected non-unions should be confirmed and immediately fixed with surgery. This treatment strategy will help to avoid the risks of surgery and mostly limit the use of surgery to fixing […]

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[Correspondence] Recurrence of breast cancer after anaesthesia

August 8, 2020 0

Summary: Daniel Sessler and colleagues1 presented the findings from their multicentre, randomised trial that compared the effect of regional anaesthesia (paravertebral block and propofol) with general anaesthesia (sevoflurane) and opioids on breast cancer recurrence and postoperative pain after potentially curative surgery. Regional anaesthesia was reported to be equivalent to general […]

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[Correspondence] Recurrence of breast cancer after anaesthesia

August 8, 2020 0

Summary: Daniel Sessler and colleagues1 compared regional (paravertebral blocks and propofol) with general (sevoflurane and opioid-based analgesia) anaesthesia on breast cancer recurrence in their randomised controlled trial. They concluded that regional anaesthesia did not reduce cancer recurrence after surgery for primary breast cancer compared with general anaesthesia. Source: The Lancet […]

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[Correspondence] Recurrence of breast cancer after anaesthesia

August 8, 2020 0

Summary: We congratulate Daniel Sessler and colleagues1 for completing their large multicentre trial, but we have concerns regarding the methodology and results. The authors report that paravertebral block techniques varied per study site across the 13 hospitals in eight countries. Typically, five levels are blocked with long-acting local anaesthetic and […]

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[Perspectives] Moral responsibility in medicine: where are the boundaries?

August 8, 2020 0

Summary: All doctors have responsibilities to protect and promote health. These responsibilities lie at the heart of medicine, providing its moral foundation. Some doctors meet their responsibilities treating individuals with diseases, some teach or do research, while others safeguard or promote the health of populations. These responsibilities arise from the […]

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[Comment] Optimal therapy for multidrug-resistant tuberculosis and HIV

August 8, 2020 0

Summary: The dual epidemics of tuberculosis and HIV have had a substantial toll on health outcomes, service delivery, and economies in many countries. Additionally, diagnosis of tuberculosis remains a challenge, especially with HIV infection, where the commonly used smears are of limited benefit; compounded by limitations of detecting drug-resistant tuberculosis.1 […]