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Novel Strategies and Platforms for Industrial Isoprenoid Engineering

April 29, 2020 Admin 0

Category: Summary: Metabolic engineering has emerged as an important tool for reconstructing heterologous isoprenoid metabolic pathways in microbial hosts. Here, we provide an overview of promising engineering strategies that have proven to be successful for the high-yield production of isoprenoids. Besides ‘conventional’ approaches, such as the ‘push–pull’ and protein engineering […]

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Clicking into Place: Interfacing Terminal Alkyne Biosynthesis with Polyketide Synthases

April 20, 2020 Admin 0

Category: Summary: Engineering polyketide biosynthesis to enable the production of diverse chemical structures is a major challenge at present. Utilising an established biosynthetic cassette for terminal alkyne production, Porterfield et al. applied docking domain and site-directed mutagenesis approaches to interface these enzymes with modular polyketide synthase (PKS) enzymes, yielding products […]

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Expanding the Reach of Recombineering to Environmental Bacteria

April 17, 2020 Admin 0

Category: Summary: Broadening the application of recombineering technologies in biotechnologically important bacteria poses significant challenges. Aparicio et al. present a vital breakthrough for efficient single-stranded recombineering by utilizing a thermoinducible system in Pseudomonas putida. This offers a simple genome-editing tool towards creating superior biocatalysts for the synthesis of chemicals and […]

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Wenjun Zhang and Sang Yup Lee: Creating an Interdisciplinary Community for Natural Products Biosynthesis

April 14, 2020 Admin 0

Category: Summary: Natural products – organic compounds synthesized by living organisms – are of immense interest for applications ranging from anticancer drugs to pigments and from flavoring components to antibiotics. These compounds can be difficult to produce using conventional synthetic chemistry, but biological systems can be engineered to synthesize natural […]

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Plant Aromatic Prenyltransferases: Tools for Microbial Cell Factories

April 13, 2020 0

Summary: In plants, prenylation of aromatic compounds, such as (iso)flavonoids and stilbenoids, by membrane-bound prenyltransferases (PTs), is an essential step in the biosynthesis of many bioactive compounds. Prenylated aromatic compounds have various health-beneficial properties that are interesting for industrial applications, but their exploitation is limited due to their low abundance […]

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Cybersecurity in Science and Medicine: Threats and Challenges

March 18, 2020 0

Summary: Technology offers opportunities to revolutionize medicine and research but can threaten privacy and patient confidentiality. As the scale of patient data explodes, the safety and integrity of medical information are increasingly at stake. We highlight security and privacy issues associated with genomic research, medical devices, and wearable technology. Source: […]