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Two Dietary Metabolites Fuel Salmonella Colonization

July 8, 2020 0

Summary: Nguyen et al. used transposon sequencing analysis and competitive colonization assays to describe how aspartate/malate can trigger initial Salmonella Typhimurium gut-lumen colonization in mice, providing insight into the significance of certain key metabolites beyond the realm of Salmonella life. Metabolite-driven diagnostic and anti-infective strategies for preventing salmonellosis could rapidly […]

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Countering Counter-Defense to Antiviral RNAi

June 10, 2020 0

Summary: RNA interference (RNAi) is a powerful host defense mechanism against viruses. As a counter-defense, many viruses encode suppressors of RNAi, which – in plants – has provoked counter-counter-defense strategies. Recently, a mechanism was proposed in Drosophila (Zhang et al.) wherein a long noncoding RNA senses a virus-encoded RNAi suppressor […]

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Chronic Immune Activation in TB/HIV Co-infection

May 29, 2020 0

Summary: With respect to the first version that was online, the fourth paragraph of the section “Mitigation of Chronic Immune Activation”, which begins with “Another promising strategy to suppress immune activation,” changed: reference numbers were corrected, text changed and two sentences were removed. Because of the renumbering of references, the […]

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Bacterial Cell Mechanics Beyond Peptidoglycan

May 25, 2020 0

Summary: The bacterial cell envelope plays essential roles in controlling cell shape, division, pathogenicity, and resistance against external stresses. In Escherichia coli, peptidoglycan (PG) has long been thought to be the primary component that conveys mechanical strength to the envelope. But a recent publication demonstrates the key contribution of the […]

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Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2

May 19, 2020 0

Summary: SARS-Coronavirus-2 (SARS-CoV-2) causes Coronavirus disease 2019 (COVID-19), an infectious respiratory disease causing thousands of deaths and overwhelming public health systems. The international spread of SARS-CoV-2 is associated with the ease of global travel, and societal dynamics, immunologic naiveté of the host population, and muted innate immune responses. Based on […]